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Osteoporosis in men

A C Scane1, A M Sutcliffe, R M Francis

  • 1University of Newcastle upon Tyne, Newcastle General Hospital, UK.

Bailliere'S Clinical Rheumatology
|October 1, 1993
PubMed
Summary

Men experience bone loss with age, increasing osteoporosis fracture risk. Hypogonadism is a key secondary cause, treatable with testosterone to improve bone density.

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Area of Science:

  • Gerontology
  • Orthopedics
  • Endocrinology

Background:

  • Bone loss and osteoporosis fractures increase in men with age, impacting forearm, vertebrae, and femur.
  • Demographic shifts predict a rise in male osteoporosis fractures, even if incidence rates stabilize.
  • Peak bone mass and subsequent bone loss are influenced by genetics, hormones, lifestyle, and nutrition.

Purpose of the Study:

  • To review the current understanding of osteoporosis in men, including risk factors and secondary causes.
  • To highlight the role of hypogonadism as a significant secondary cause of osteoporosis in men.
  • To discuss potential treatment strategies for male osteoporosis.

Main Methods:

  • Literature review of studies on male osteoporosis.
  • Analysis of demographic trends and fracture incidence in aging male populations.
  • Examination of etiological factors, including hormonal and genetic influences.

Main Results:

  • Osteoporotic fractures are rising in men due to population aging.
  • Secondary causes, particularly hypogonadism (up to 20%), are prevalent in men with vertebral fractures.
  • Testosterone treatment can reverse bone loss in hypogonadal osteoporosis.

Conclusions:

  • Osteoporosis is a significant concern for aging men, with increasing fracture incidence.
  • Identifying and treating secondary causes like hypogonadism is crucial for managing male osteoporosis.
  • Further clinical trials are needed to confirm the efficacy of treatments like calcitonin, bisphosphonates, and testosterone.

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