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Significance of autoantibodies to purified proteinase 3 in systemic vasculitis
G Gaskin1, A N Turner, J J Ryan
1Department of Medicine, Royal Postgraduate Medical School, London, UK.
Advances in Experimental Medicine and Biology
|January 1, 1993
Abstract:
Proteinase 3 was purified from human neutrophils and used in ELISA to examine sera from 150 patients with systemic vasculitis. It was found to be the major target of autoantibodies in Wegener's granulomatosis, and anti-proteinase 3 antibodies were also found in some patients with microscopic polyarteritis. Anti-proteinase 3 antibodies were associated with a chronic relapsing course.