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Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Antibodies to neutrophil cytoplasmic antigens in rheumatoid arthritis
1Department of Rheumatology, Charing Cross Hospital, London, UK.
Advances in Experimental Medicine and Biology
|January 1, 1993
Abstract:
In this study we examined the sera from 42 randomly selected patients with RA. ANCA was demonstrated by indirect immunofluorescence on human granulocytes in 10 patients with active disease and in none of the patients with inactive disease. ELISA's for the detection of specific antigens showed the presence of anti-myeloperoxidase in 3 patients, and anti-lactoferrin in 1 patient. The specificity of the remaining antibodies was unidentified. All 3 patients with antibodies to myeloperoxidase had vasculitis.
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