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Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis
M Varagunam1, A C Nwosu, D Adu
1Renal Research Laboratory, Queen Elizabeth Hospital, Edgbaston, Birmingham.
Advances in Experimental Medicine and Biology
|January 1, 1993
Abstract:
Sera from patients with a vasculitis and controls were investigated for the presence of anti-endothelial cell antibodies(AECA), anti- neutrophil cytoplasmic antibodies(ANCA) and anti-myeloperoxidase (MPO) antibodies. Only 19% of patients with Wegener's granulomatosis and 2% of patients with microscopic polyarteritis had AECA. Our data suggests that AECA are a minor antibody system in vasculitis.