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Related Experiment Videos

Growth hormone--non multum sed multa (quality, not quantity)

A Shulman1, R Maymon, C Bahary

  • 1Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.

International Journal of Fertility and Menopausal Studies
|September 1, 1993
PubMed
Summary

Recombinant human growth hormone (GH) reduces the need for gonadotropins in ovulation induction but offers minimal pregnancy benefits. Guidelines are provided for appropriate patient selection.

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Area of Science:

  • Reproductive Endocrinology
  • Hormone Therapy

Background:

  • Recombinant human growth hormone (GH) is now available.
  • GH may augment ovulation induction with exogenous gonadotropins.

Purpose of the Study:

  • To survey the reproductive physiological role of GH.
  • To evaluate clinical studies using GH for ovulation induction.
  • To suggest an explanation for observed pregnancy rates and provide recommendations.

Main Methods:

  • Literature review of GH's reproductive role.
  • Analysis of clinical studies on GH in ovulation induction.

Main Results:

  • GH significantly reduces exogenous gonadotropin requirements.
  • GH shows only minor benefits in achieving pregnancy.

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  • An explanation for limited pregnancy success is proposed.
  • Conclusions:

    • GH is effective in reducing gonadotropin dosage for ovulation induction.
    • Pregnancy rate improvements with GH are minimal.
    • Guidelines for selecting patients for GH therapy are presented.