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Furosemide, bumetanide, and ethacrynic acid
1Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus.
The Veterinary Clinics of North America. Equine Practice
|December 1, 1993
Summary
Furosemide and other diuretics are given to horses to prevent bleeding during exercise. These drugs alter urine and blood composition, affecting overall health and performance in equine athletes.
Area of Science:
- Veterinary Medicine
- Equine Physiology
- Pharmacology
Background:
- Furosemide, bumetanide, and ethacrynic acid are potent diuretics used in horses.
- Commonly administered for exercise-induced pulmonary hemorrhage (EIPH) prophylaxis.
- These diuretics impact urine volume, composition, and systemic hemodynamics.
Purpose of the Study:
- To summarize the effects of furosemide and related diuretics in horses.
- To highlight their role in managing conditions like EIPH.
- To discuss their physiological impacts on equine athletes.
Main Methods:
- Review of existing literature on diuretic use in horses.
- Analysis of physiological effects on urine and plasma.
- Examination of hemodynamic changes at rest and during exercise.
Main Results:
- Furosemide significantly alters plasma volume and composition.
- Diuretics affect urine output and electrolyte concentrations.
- Systemic hemodynamics are modified by these agents in horses.
Conclusions:
- Diuretics like furosemide are crucial in equine sports medicine.
- Understanding their effects is vital for safe and effective administration.
- Further research may elucidate optimal protocols for performance enhancement and health management.