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Related Experiment Videos

Tolerance induction as a multi-step process

G Schönrich1, J Alferink, A Klevenz

  • 1Tumor Immunology Program, German Cancer Research Center, Heidelberg.

European Journal of Immunology
|February 1, 1994
PubMed
Summary

Tolerant T cells remain receptive to further tolerogenic signals, even after initial tolerance induction. Further encounters with antigen-presenting cells, like hepatocytes, can lead to the deletion of these previously tolerant T cells.

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Area of Science:

  • Immunology
  • T cell biology
  • Tolerance induction

Background:

  • Tolerant T cells exhibit resistance to antigen activation.
  • The susceptibility of tolerant T cells to subsequent tolerogenic signals remains unclear.

Purpose of the Study:

  • To investigate if tolerant T cells can be further tolerized.
  • To understand the multi-step nature of tolerance induction.

Main Methods:

  • Utilized transgenic T cell receptor (TCR) mice specific for MHC class I molecule Kb.
  • Administered Kb-positive cells intravenously and examined T cell deletion.
  • Expressed Kb on hepatocytes to assess T cell tolerance.

Main Results:

  • T cells tolerant in vivo were activated in vitro by Kb antigen.

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  • In vitro reactivity was abolished upon encounter with intravenously injected Kb-positive cells.
  • Tolerant T cells were deleted when Kb was expressed on hepatocytes.

    • Conclusions:

    • Tolerance induction is a dynamic, multi-step process.
    • Tolerant T cells can be receptive to additional tolerogenic signals, leading to their elimination.