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Optic neuropathy associated with clomiphene citrate therapy
1Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans.
Fertility and Sterility
|February 1, 1994
Summary
Clomiphene citrate (CC) may cause vision loss by affecting blood flow to the optic nerve. Prompt eye examinations are crucial for patients experiencing visual symptoms while taking this infertility drug.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Clomiphene citrate (CC) is a common medication used to treat infertility.
- Vascular effects of CC, such as sludging, have been previously reported.
Observation:
- A 31-year-old woman experienced acute visual loss in her right eye shortly after a 5-day course of CC for primary infertility.
- Vision partially recovered but did not return to baseline acuity.
Findings:
- The visual loss is hypothesized to be anterior ischemic optic neuropathy.
- This may result from reduced blood flow in a posterior ciliary artery due to CC-induced increases in blood viscosity.
Implications:
- Patients on CC experiencing visual disturbances require immediate ophthalmological evaluation.
- Early detection of optic nerve injury or visual changes is critical for managing potential CC-related ocular complications.