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Related Experiment Videos

Sub-50 oral contraceptives affect folate kinetics

R P Steegers-Theunissen1, J M Van Rossum, E A Steegers

  • 1Department of Obstetrics and Gynecology, University Hospital St. Radboud, Nijmegen, The Netherlands.

Gynecologic and Obstetric Investigation
|January 1, 1993
PubMed
Summary

Long-term use of low-estrogen oral contraceptives (OCs) impacts folate and vitamin B12 levels. While affecting folate kinetics and vitamin B12, oral contraceptive use does not appear to put nutrient status at risk.

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Area of Science:

  • Nutritional Science
  • Endocrinology

Background:

  • Oral contraceptives (OCs) are widely used by women of reproductive age.
  • Sub-50 OCs contain less than 50 micrograms of estrogen.
  • Potential effects of OCs on nutrient status require investigation.

Purpose of the Study:

  • To investigate the effects of long-term sub-50 OC use on folate, vitamin B12, and iron status.
  • To assess the impact on folate kinetics and serum concentrations of vitamin B12.

Main Methods:

  • Study included 29 women using Marvelon (sub-50 OC) and 13 controls.
  • Folate kinetics were assessed after oral folate loading.
  • Serum folate, vitamin B12, and iron status markers were measured.

Main Results:

Related Experiment Videos

  • OC users had significantly lower serum folate 210 min post-loading compared to controls.
  • Significantly higher total iron-binding capacity was observed in OC users.
  • Serum vitamin B12 concentrations were significantly lower in women using sub-50 OCs.

Conclusions:

  • Sub-50 oral contraceptives significantly influence folate kinetics and vitamin B12 levels.
  • Despite observed changes, the overall folate and vitamin B12 status in OC users is not compromised.
  • Further research may explore long-term implications and optimal supplementation strategies.