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Related Experiment Videos

Aging and growth hormone

K K Ho1, D M Hoffman

  • 1Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia.

Hormone Research
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Growth hormone (GH) secretion declines with age, impacting body composition. While GH treatment shows promise in the elderly, safety and dosage require further investigation before widespread use.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Neuroscience

Background:

  • Growth hormone (GH) is produced throughout life, but its secretion significantly decreases with age, reaching levels comparable to GH deficiency in adults.
  • Age-related decline in GH is influenced by neuroendocrine function, nutrition, and sex hormones.

Purpose of the Study:

  • To investigate the role of diminished GH action in age-related changes in body composition and function.
  • To evaluate the potential benefits and risks of GH treatment in the elderly population.

Main Methods:

  • Review of studies on GH secretion ontogeny and GH treatment outcomes in adults and the elderly.
  • Analysis of changes in body composition and function associated with aging and GH deficiency.

Main Results:

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  • GH levels in the elderly often fall below assay detection limits, similar to individuals with organic GH deficiency.
  • GH treatment in GH-deficient adults has shown beneficial effects on body composition and function.
  • Preliminary studies in the normal elderly suggest potential benefits for body composition but highlight a high incidence of side effects.

Conclusions:

  • Diminished GH action may contribute to undesirable aging-related changes.
  • GH treatment in the elderly shows potential but requires careful consideration of cost, benefit, dosage, safety, and tolerance.
  • Further critical evaluation is needed before GH therapy can be recommended for the aging population.