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Duodenal manometry in postobstructive enteropathy in infants with a transient enterostomy
J P Cezard1, G Cargill, C Faure
1Service de Gastroentérologie Pédiatrique et de Chirurgie, Hôpital Robert Debre, Paris, France.
Insights
Neonatal intestinal obstruction can cause chronic motility issues in children, leading to postobstructive enteropathy. This study found altered migrating motor complex patterns and reduced motility index in affected children.
Area of Science:
- Pediatric Gastroenterology
- Neonatal Surgery
- Motility Disorders
Background:
- Neonatal intestinal obstruction can lead to transient enterostomy.
- Postobstructive enteropathy is a potential complication.
- Understanding motility alterations is crucial for management.
Purpose of the Study:
- To investigate intestinal motility in children with transient enterostomy post-obstruction.
- To correlate motility abnormalities with clinical presentation and enteropathy severity.
- To elucidate the pathophysiology of postobstructive enteropathy.
Main Methods:
- Studied 11 children with transient enterostomy due to various neonatal obstructions.
- Assessed motility using barium small intestine transit and duodenal manometry.
- Classified patients into clinical groups based on nutritional support and feeding tolerance.
Main Results:
- Abnormal inert marker transit times correlated with clinical groups and manometric findings.
- Manometry revealed absent or abnormal phase III of the migrating motor complex (MMC).
- Reduced motility index was observed in patients with postobstructive enteropathy.
Conclusions:
- Postobstructive enteropathy is characterized by chronic alterations in intestinal motility.
- Prenatal or postnatal obstructions induce these motility changes.
- Findings confirm motility dysfunction as a key factor in this condition.
Abstract:
Intestinal motility was studied in 11 children with a transient enterostomy secondary to a neonatal organic small intestine obstruction (5 total colon Hirschsprung's disease, 2 necrotizing enterocolitis, 1 intussusception, 3 ileal atresia). Eight children presented with a postobstructive enteropathy (severe grade I [5], moderate grade II [3]) and three were considered as controls (grade III). They were assigned to one of the three groups on the basis of the duration of parenteral nutrition and constant rate enteral nutrition needed and the oral feeding tolerance. Barium small intestine transit showed no persistent partial obstruction or peritoneal adhesions. The abnormal inert marker transit times were statistically correlated with the clinical groups as well as duodenal manometric abnormalities. Manometric recordings were characterised by the absence (grade I) or abnormal phase III (grade II) of the migrating motor complex and decreased motility index (grades I and II). This study confirms that this enteropathy is due to a chronic alteration in motility induced by prenatal or postnatal obstructions.
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