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Ocular manifestations in bone marrow transplantation
Journal of Ophthalmic Nursing & Technology
|September 1, 1993
Summary
Bone marrow transplants for acute leukemia can cause serious eye problems, including dry eye and vision loss. Graft-versus-host disease significantly worsens these ocular complications, requiring regular ophthalmologist monitoring.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Bone marrow transplantation is a standard treatment for acute leukemia.
- Graft-versus-host disease (GVHD) is a frequent and serious complication, affecting 50-70% of patients.
- Ocular complications can affect both the anterior and posterior segments of the eye.
Purpose of the Study:
- To highlight the significant risk of ocular complications following bone marrow transplantation for acute leukemia.
- To emphasize the role of GVHD in exacerbating eye conditions.
- To recommend routine ophthalmological surveillance for these patients.
Main Methods:
- Review of ocular complications in bone marrow transplant recipients.
- Analysis of the impact of GVHD on eye health.
- Inclusion of findings from relevant studies, such as Lopez et al. on retinopathy.
Main Results:
- High incidence of dry eye syndrome, viral keratitis, and corneal trophic disturbances.
- GVHD is associated with increased frequency and severity of ocular involvement.
- Occlusive microvascular retinopathy was observed in 62% of patients surviving at least 6 months post-transplant.
Conclusions:
- Patients undergoing bone marrow transplantation require vigilant ophthalmological monitoring due to high risks of eye complications.
- GVHD is a critical factor influencing the development and severity of these ocular issues.
- Early detection and management are crucial for preserving vision in leukemia patients post-transplant.