Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hemodynamics and the vascular endothelium

¹School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332-0405.

Journal of Biomechanical Engineering

|November 1, 1993

Summary

The endothelium responds dynamically to blood flow and mechanical forces. These hemodynamic forces influence endothelial cell structure, function, and gene expression, impacting vascular biology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tissue engineering: from biology to biological substitutes.

Tissue engineering·2009

Same author

Tissue engineering: from basic science to products: a preface.

Tissue engineering·2009

Same author

The role of fluid mechanics in atherogenesis.

Journal of biomechanical engineering·2009

Same author

Bioengineered tissues: the science, the technology, and the industry.

Orthodontics & craniofacial research·2005

Same author

Tissue engineering of the vascular system.

Vox sanguinis·2004

Same author

Endothelial cell monolayer formation: effect of substrate and fluid shear stress.

Endothelium : journal of endothelial cell research·2004

Area of Science:

Cardiovascular Biology
Cellular Mechanotransduction

Background:

The endothelium, previously viewed as a passive barrier, is now understood as a dynamic regulator of vascular health.
Hemodynamics significantly influence endothelial cell behavior and vascular pathobiology.

Purpose of the Study:

To investigate the impact of mechanical forces, specifically flow and cyclic stretch, on vascular endothelial cells.
To understand how endothelial cells sense and respond to their mechanical environment.

Main Methods:

Utilizing in vitro cell culture systems to apply controlled flow and cyclic stretch.
Analyzing changes in endothelial cell structure, function, and gene expression.

Main Results:

Endothelial cells exhibit modulated structure and function in response to flow-induced shear stress.
Cyclic stretch in cell culture models demonstrates similar modulatory effects.
Mechanical forces lead to differential regulation of messenger RNA (mRNA) expression.

Conclusions:

Hemodynamic forces are critical modulators of endothelial cell biology.
Endothelial cells possess mechanisms to recognize and transduce mechanical signals.
Signal transduction pathways involved in chemical sensing are also implicated in mechanical signal transduction.

Related Experiment Videos