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Related Experiment Videos

Serial assessment of acute stroke using the NIH Stroke Scale

R J Wityk1, M S Pessin, R F Kaplan

  • 1Department of Neurology (Stroke Service), New England Medical Center, Boston, Mass.

Stroke
|February 1, 1994
PubMed
Summary

Patients with acute ischemic stroke treated conventionally show significant recovery within days, as measured by the National Institutes of Health (NIH) Stroke Scale. Stroke type may influence the speed and extent of neurological improvement.

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Area of Science:

  • Neurology
  • Clinical Neuroscience
  • Stroke Medicine

Background:

  • The National Institutes of Health (NIH) Stroke Scale is a standard tool for assessing neurological deficits in acute stroke clinical trials.
  • Conventional therapy is the standard treatment for many acute stroke patients.

Purpose of the Study:

  • To evaluate the degree and time course of neurological recovery in acute ischemic stroke patients receiving conventional therapy.
  • To assess recovery patterns using the NIH Stroke Scale.

Main Methods:

  • Serial assessment of 50 acute ischemic stroke patients presenting within 24 hours of symptom onset.
  • Patients were categorized by stroke subtype.
  • Major neurological improvement was defined as a ≥4-point decrease in NIH Stroke Scale score.

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Main Results:

  • Mean NIH stroke scores improved significantly by 7–10 days and at a mean follow-up of 44 days.
  • By follow-up, 51% of patients achieved major neurological improvement.
  • Patients with middle cerebral artery territory embolism showed improvement, while those with lacunar infarcts did not show significant score changes.

Conclusions:

  • A substantial proportion of acute ischemic stroke patients treated conventionally experience early neurological improvement.
  • The type of stroke may impact the recovery trajectory and NIH Stroke Scale score changes.