[The genomic variability of adenovirus serotype 3]

Genetic heterogeneity and evolutionary relationships among selected strains of adenovirus type 3 (Ad3) isolated in the former USSR (1976-1988) were examined using the restriction endonuclease Cfr131 with a 4-base recognition cleavage site. The population of adenovirus type 3 showed significant genetic instability. Evolution of genomic variants of Ad3 was found to have regional localization associated with definite periods of adenovirus circulation.