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The genetics of psoriasis

J T Elder1, R P Nair, S W Guo

  • 1Department of Dermatology, University of Michigan, Ann Arbor.

Archives of Dermatology
|February 1, 1994
PubMed
Summary

Psoriasis susceptibility is heritable and strongly linked to the Human Leukocyte Antigen (HLA) complex, but not solely determined by it. Further genetic factors, discoverable through genomic research, are crucial for understanding disease development.

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Area of Science:

  • Immunogenetics
  • Human Genetics
  • Dermatology

Background:

  • Psoriasis is a common, heritable disease with strong Human Leukocyte Antigen (HLA) associations.
  • Simple Mendelian inheritance models do not fully explain psoriasis susceptibility.
  • Only a subset of individuals with associated HLA alleles develop psoriasis, suggesting additional genetic or environmental factors.

Purpose of the Study:

  • To analyze epidemiologic and immunogenetic data to understand psoriasis heritability and HLA associations.
  • To explore the potential for identifying additional genetic determinants of psoriasis using emerging genomic technologies.

Main Methods:

  • Review and analysis of existing epidemiologic and immunogenetic data.
  • Discussion of recent advancements in human genome research relevant to complex disease genetics.

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Main Results:

  • Psoriasis predisposition is heritable, with HLA genes being necessary but insufficient determinants.
  • The Human Leukocyte Antigen (HLA) locus shows a strong association with psoriasis.
  • Genomic research enables systematic searches for additional, potentially unlinked, genetic factors.

Conclusions:

  • Psoriasis, due to its high heritability and strong HLA association, is an ideal model for applying new genomic technologies.
  • Identifying additional genetic determinants is key to a comprehensive understanding of psoriasis pathogenesis.