Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin action and substrate competition

L C Groop1, E Ferrannini

  • 1University of Lund, Department of Endocrinology, Malmõ General Hospital, Sweden.

Bailliere'S Clinical Endocrinology and Metabolism
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: A ten-year follow-up study.

Diabetes & metabolism·2021
Same author

Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in man.

Metabolism: clinical and experimental·2019
Same author

Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2017
Same author

Obesity and carotid artery remodeling.

Nutrition & diabetes·2015
Same author

The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment.

Diabetes, obesity & metabolism·2014
Same author

Type 1 diabetes and (C-X-C motif) ligand (CXCL) 10 chemokine.

La Clinica terapeutica·2014
Same journal

Phytoestrogen content in foods.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Experimental studies on lignans and cancer.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Reproductive actions of phytoestrogens.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and inhibition of angiogenesis.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and diseases of the prostate gland.

Bailliere's clinical endocrinology and metabolism·1999
See all related articles

Free fatty acids (FFAs) compete with glucose metabolism, contributing to insulin resistance in obesity and type 2 diabetes. Weight loss can reverse obesity-related insulin resistance, while NIDDM defects are partially irreversible.

Area of Science:

  • Metabolic Regulation
  • Endocrinology
  • Obesity Research

Background:

  • Increased free fatty acid (FFA) oxidation impairs glucose oxidation and insulin's effect on hepatic glucose production.
  • Skeletal muscle exhibits substrate competition between glucose and FFAs, affecting pyruvate oxidation and glycogen synthesis.
  • Obesity-related insulin resistance is metabolic and reversible with weight reduction; NIDDM-related insulin resistance is primary, genetic, and partially irreversible.

Purpose of the Study:

  • To investigate the role of substrate competition in insulin resistance.
  • To explore the potential of manipulating the glucose-FFA cycle for therapeutic benefit.
  • To examine the impact of FFAs on glucose metabolism in obesity and NIDDM.

Main Methods:

  • Review of existing evidence on substrate competition between FFAs and glucose in human skeletal muscle.

Related Experiment Videos

  • Analysis of the metabolic consequences of increased FFA oxidation in insulin resistance.
  • Discussion of therapeutic strategies targeting FFA oxidation and glycogen synthesis.

    • Main Results:

    • Elevated FFA oxidation reduces glucose oxidation and insulin sensitivity.
    • Weight reduction can reverse FFA-induced insulin resistance.
    • NIDDM involves impaired glucose oxidation and compensatory lipid oxidation, with partially irreversible defects.

    Conclusions:

    • Substrate competition between glucose and FFAs is a key factor in insulin resistance.
    • Therapeutic interventions targeting FFA oxidation and glycogen synthesis show potential but require further investigation.
    • The glucose-FFA-amino acid cycle integrates substrate disposition, offering a broader perspective on metabolic control.