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Updated: Aug 11, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
Published on: October 30, 2015
Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands
B D Evavold1, J Sloan-Lancaster, P M Allen
1Dept of Pathology, Washington University School of Medicine, St Louis, MO 63110.
Abstract:
Recent observations of T-cell responses following T-cell receptor (TCR) interaction with altered peptide ligands have highlighted the complexity of this signalling system. The indications are that the TCR responds to minor changes in ligand with gradations of T-cell activation and effector functions. Brian Evavold, Joanne Sloan-Lancaster and Paul Allen review these studies and present a model in which partial T-cell activation and TCR antagonism are related events in a continuum of signalling through the TCR.
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