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Updated: Aug 17, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Cervical cancer, human papillomavirus and vaccines
1United Medical School, Guy's Hospital (UMDS), London, UK.
Abstract:
HPV-16 has been strongly implicated in the aetiology of cervical cancer and pre-malignant cervical intraepithelial neoplasia. Despite current technical difficulties it may soon be possible to treat these tumours with anti-HPV-16 vaccines. A prophylactic vaccine could, in theory, be developed to induce neutralizing antibodies to HPV-16 virions in genital secretions, and a therapeutic vaccine to elicit cytotoxic T-cell responses against established lesions.
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