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Related Experiment Videos

Fluvoxamine-associated manic behavior: a case series

A Dorevitch1, Y Frankel, A Bar-Halperin

  • 1Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.

The Annals of Pharmacotherapy
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

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Fluvoxamine, a selective serotonin-reuptake inhibitor, may induce manic-like behavior in some patients. Symptoms resolved upon fluvoxamine dose adjustment or discontinuation, highlighting the need for careful monitoring.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Selective serotonin-reuptake inhibitors (SSRIs) are widely prescribed for depression and obsessive-compulsive disorder.
  • Antidepressant-induced mania is a recognized phenomenon, particularly with SSRIs.

Observation:

  • A case series involving eight patients who developed manic-like behavior after initiating fluvoxamine therapy.
  • These patients had diagnoses of depression or obsessive features.

Findings:

  • Manic symptomatology resolved in all eight patients after fluvoxamine dosage reduction or withdrawal.
  • Four patients remained stable on low-dose fluvoxamine without recurrence of manic symptoms.

Implications:

  • Fluvoxamine may induce or unmask manic behavior in susceptible individuals.

Related Experiment Videos

  • Clinicians should monitor patients for antidepressant-induced mania, especially those with a history of bipolar disorder, obsessive-compulsive disorder, or those on concurrent neuroleptic or lithium treatment.