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Related Experiment Videos

Amiodarone-clonazepam interaction

D M Witt1, A J Ellsworth, J H Leversee

  • 1Kaiser Permanente, Westminster, CO 80234.

The Annals of Pharmacotherapy
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

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A potential drug interaction between amiodarone and clonazepam was observed. Amiodarone may inhibit clonazepam metabolism, increasing toxicity risk, necessitating careful patient monitoring.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Amiodarone, a Class III antiarrhythmic, is used for ventricular tachycardia.
  • Clonazepam, a benzodiazepine, is prescribed for conditions like restless leg syndrome.

Observation:

  • A patient receiving amiodarone developed symptoms of benzodiazepine toxicity after starting clonazepam.
  • The toxicity symptoms resolved upon discontinuation of clonazepam.

Findings:

  • Amiodarone inhibits oxidative microsomal enzymes, potentially impairing the metabolism of drugs like clonazepam.
  • Hypothyroidism, a known side effect of amiodarone, can also affect drug metabolism and central nervous system sensitivity.

Implications:

  • Concomitant use of amiodarone and clonazepam requires close monitoring due to the risk of altered drug disposition and toxicity.

Related Experiment Videos

  • Healthcare providers should be aware of this potential interaction when prescribing these medications together.