[Microvascular monitoring using mercury in silastic strain gauge plethysmography (MSG)]

Mercury in silastic strain gauge plethysmography (MSG) is a noninvasive method for assessing microvascular parameters in peripheral limbs. MSG allows measurement of capillary filtration coefficient (Kf), isovolumetric venous pressure (Pvi), venous pressure (Pv) and arterial inflow (Qa) into the limb, respectively. We used MSG in combination with invasive monitoring techniques (pulmonary artery flotation catheters and arterial catheters) to study 36 critically ill patients in either hemorrhagic or septic shock. We observed marked increases in Pvi in both patient groups which correlated with outcome. On admission, both groups showed elevated values for Pvi, survivors 37.7 +/- 2.6, nonsurvivors 33.7 +/- 3.5 mm Hg (mean +/- SEM) when compared with a control group of young healthy students (22.1 +/- 0.82 mm Hg). Survivors showed a decrease in Pvi to 27.3 +/- 1.7 mm Hg, whereas in nonsurvivors Pvi increased to 39.5 +/- 3.0 at the last measurement taken. The changes in Pvi depended on the resuscitation regime used. On admission, patients requiring only fluid replacement (F) had a lower Pvi (31.3 +/- 2.9 mm Hg) than patients needing inotropic support with dobutamine (D, Pvi = 38.2 +/- 2.4 mm Hg) to fulfill our therapeutic goals (DO2 > 550 ml.min-1 x m-2, VO2 > 150 ml.min-1 x m-2 and mixed venous lactate < 1.5 mmol/l). After treatment Pvi did not change significantly in the F group (31.3 +/- 1.8), the D group however showed a significant decrease in Pvi to 25.4 +/- 2.42, which did not differ from the normal value. We regard Pvi as an indicator of insufficient microvascular flow.(ABSTRACT TRUNCATED AT 250 WORDS)