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Effect of testosterone administration on upper airway collapsibility during sleep
P A Cistulli1, R R Grunstein, C E Sullivan
1Sleep Disorders Center, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
American Journal of Respiratory and Critical Care Medicine
|February 1, 1994
Summary
Testosterone may worsen obstructive sleep apnea (OSA) by increasing upper airway collapsibility. This effect reversed after stopping testosterone, suggesting a link to neuromuscular control of the airway.
Area of Science:
- Endocrinology
- Sleep Medicine
- Respiratory Physiology
Background:
- Obstructive sleep apnea (OSA) is a common sleep disorder.
- Testosterone's role in OSA pathogenesis is suspected but not fully understood.