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[Monoclonal antibodies against D-antigen of the rhesus system]

N I Olovnikova, E I Deriugina

    Gematologiia I Transfuziologiia
    |July 1, 1993
    PubMed

    The authors review current data on the production and characterization of anti-D monoclonal antibodies. The main methods for establishment of anti-D antibody secreting cell lines are considered: EBV-transformation of B lymphocytes from immune donor and hybridization with malignant human or murine cell lines. Serologic and immunological properties of anti-D monoclonal reagents for blood group Rh-typing as well as feasibility of using anti-D monoclonal antibodies as a modality against hemolytic disease of the newborn are discussed.

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