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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Coeliac disease in the elderly

G L Hankey¹, G K Holmes

¹Department of Gastroenterology, Derbyshire Royal Infirmary, Derby.

|January 1, 1994

Summary

Late diagnosis of coeliac disease is common in elderly patients, with many experiencing years of unexplained symptoms. Early diagnosis and a gluten-free diet significantly improve health outcomes for older adults with this condition.

Area of Science:

Gastroenterology
Internal Medicine
Geriatrics

Background:

Adult coeliac disease (ACD) is often diagnosed late, particularly in elderly individuals.
A significant proportion of elderly patients present with non-specific symptoms and diagnostic delays.
Untreated coeliac disease can lead to various complications and reduced quality of life.

Purpose of the Study:

To investigate the diagnostic delay and clinical characteristics of coeliac disease in elderly patients.
To assess the impact of a gluten-free diet on symptom resolution and biochemical parameters in older adults with coeliac disease.

Main Methods:

Retrospective analysis of 228 adult coeliac disease patients.
Focus on patients diagnosed at age 60 years or older.

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Evaluation of symptom changes and biochemical markers before and after a gluten-free diet.

Main Results:

19% of adult coeliac disease patients were diagnosed at age 60 or over.
15 out of 35 patients without dermatitis herpetiformis had a diagnostic delay averaging 28 years.
Gluten-free diet adherence led to symptom resolution and significant improvements in weight, hemoglobin, albumin, calcium, and alkaline phosphatase levels within a year.

Conclusions:

Coeliac disease should be considered in the elderly, especially those with unexplained anemia and non-specific complaints.
Timely diagnosis and strict adherence to a gluten-free diet are crucial for managing coeliac disease in older adults.
Early intervention can reverse clinical and biochemical abnormalities associated with coeliac disease in the elderly.