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Esophageal dysfunction does not always worsen in systemic sclerosis

R O Dantas1, U G Meneghelli, R B Oliveira

  • 1Department of Internal Medicine, Faculty of Medicine, Ribeirão Preto University of São Paulo, Brazil.

Journal of Clinical Gastroenterology
|December 1, 1993
PubMed
Summary

Systemic sclerosis (SSc) can affect the esophagus, but manometric studies show esophageal involvement is not always progressive in SSc patients. Some patients exhibit stable esophageal function over time.

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Clinical Physiology

Background:

  • Systemic sclerosis (SSc) is a connective tissue disease that frequently affects the esophagus.
  • Esophageal dysfunction is a common complication of SSc, impacting patient quality of life.

Purpose of the Study:

  • To investigate the progression of esophageal involvement in women with systemic sclerosis (SSc) using esophageal manometry.
  • To compare esophageal function over time in SSc patients and with healthy controls.

Main Methods:

  • Esophageal manometry was performed on 17 women with SSc and 14 healthy women.
  • SSc patients underwent a second manometric examination after a median interval of 40 months.
  • Key parameters analyzed included peristaltic contractions, lower esophageal sphincter (LES) pressure, and contraction amplitude, duration, and velocity.

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Main Results:

  • SSc patients exhibited reduced LES pressure and contraction amplitude compared to controls.
  • While proximal esophageal peristalsis was preserved, middle and distal esophageal contractions were impaired in a significant portion of SSc patients.
  • Esophageal function remained stable in 16 out of 17 SSc patients over the study interval, with one patient showing significant deterioration.

Conclusions:

  • Esophageal involvement in systemic sclerosis is not universally progressive.
  • Manometric assessment reveals heterogeneous patterns of esophageal dysfunction in SSc patients.
  • Longitudinal studies indicate stability of esophageal function in most SSc patients, challenging the assumption of constant progression.