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[123I-OIH renoscintigraphy in children with chronic disorder of glomerulus]
J Okada1, H Oonishi, K Sanayama
1Department of Radiology, Narita Red Cross Hospital, Chiba, Japan.
Insights
123I-orthoiodohippurate (OIH) renography effectively evaluates pediatric kidney function in chronic glomerulonephritis. This imaging technique reveals renal hypofunction when other tests are normal, aiding diagnosis in children.
Area of Science:
- Pediatric Nephrology
- Nuclear Medicine
- Diagnostic Imaging
Background:
- Chronic glomerulonephritis and nephrotic syndrome can impair renal function in children.
- Standard laboratory tests may not always detect early functional changes.
- Accurate assessment of renal function is crucial for managing pediatric kidney diseases.
Purpose of the Study:
- To assess the diagnostic utility of 123I-orthoiodohippurate (OIH) renography in pediatric patients with chronic glomerular disorders.
- To compare OIH renography findings with conventional laboratory markers of renal function.
- To determine if OIH renography can detect subclinical renal dysfunction.
Main Methods:
- Studied 31 pediatric patients (5-15 years) with chronic glomerular disorders.
- Performed 123I-OIH renography to obtain time-activity curves.
- Analyzed parameters like Tmax and T 1/2 from renograms.
- Correlated renography results with BUN, PSP test, and creatine clearance.
Main Results:
- Statistically prolonged Tmax and T 1/2 were observed in patients with chronic glomerulonephritis and steroid-resistant nephrotic syndrome.
- Most renograms indicated a hypofunction pattern.
- Conventional laboratory tests (BUN, PSP, creatine clearance) often showed normal values despite renographic abnormalities.
Conclusions:
- 123I-OIH renography is a sensitive and valuable tool for evaluating renal function in pediatric patients with chronic glomerulonephritis.
- OIH renography can detect renal hypofunction not evident in standard laboratory tests.
- This imaging modality aids in the early diagnosis and management of pediatric kidney disease.
Abstract:
To evaluate the usefulness of 123I-orthoiodohippurate (OIH) renography, 31 patients with chronic disorder of glomerulus, from 5 years to 15 years old, were studied. In chronic glomerulonephritis and nephrotic syndrome with resistance to steroid therapy, Tmax and T 1/2 of the time-activity curve were statistically prolonged. Most of the renograms (time-activity curves) of the patients showed the hypofunction pattern. In most of the patients, other laboratory data, including BUN, PSP test and creatine clearance, didn't show abnormal values. 123I-OIH scan was considered to be a sensitive and useful method to evaluate the renal function in pediatric patients with chronic glomerulonephritis.