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Bone marrow acid phosphatase: prognostic value in patients undergoing radical prostatectomy
The Journal of Urology
|January 1, 1977
Summary
Elevated preoperative bone marrow acid phosphatase levels in prostate cancer patients indicate a higher risk of metastasis. This finding aids in predicting disease progression after radical prostatectomy.
Area of Science:
- Oncology
- Biochemistry
Background:
- Acid phosphatase is an enzyme found in the prostate.
- Elevated levels can be indicative of prostate cancer progression.
Purpose of the Study:
- To investigate the correlation between preoperative bone marrow acid phosphatase levels and the incidence of metastasis in patients undergoing radical prostatectomy.
Main Methods:
- Measurement of bone marrow acid phosphatase levels before surgery.
- Review of surgical pathology and clinical follow-up data.
Main Results:
- 18 out of 31 patients (58%) showed elevated bone marrow acid phosphatase levels preoperatively.
- Patients with elevated levels demonstrated a higher incidence of metastasis.
Conclusions:
- Preoperative bone marrow acid phosphatase may serve as a predictive biomarker for metastasis in prostate cancer patients.
- This biomarker can potentially inform treatment strategies and prognosis assessment.