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Hepatitis B vaccination in prisons: the Catalonian experience
J M Bayas1, M Bruguera, V Martin
1Servicio de Medicina Preventiva, Hospital Clinic i Provincial, Barcelona, Spain.
Vaccine
|November 1, 1993
Summary
Hepatitis B vaccination in prisons offered protection to a third of susceptible inmates. Shorter intervals between vaccine doses improved immune response and adherence in this high-risk population.
Area of Science:
- Public Health
- Vaccinology
- Infectious Disease Epidemiology
Background:
- Prisons house high-risk populations for hepatitis B virus (HBV) infection.
- Limited data exists on the feasibility and effectiveness of HBV vaccination programs within correctional facilities.
Purpose of the Study:
- To evaluate the feasibility and serological response to a pilot hepatitis B vaccination program in a male prison population.
- To identify factors influencing vaccine response and adherence in inmates.
Main Methods:
- A pilot vaccination program offered hepatitis B vaccine to HBV-seronegative inmates.
- Antibody response (anti-HBs) was assessed after two or three vaccine doses.
- Vaccination completion rates and factors associated with response were analyzed.
Main Results:
- 41% of inmates were candidates for vaccination; 33% completed the full series.
- Seroconversion rates were 33% after two doses and 76% after three doses.
- Shorter intervals (<3 weeks) between initial doses significantly increased seroconversion (91%).
Conclusions:
- Hepatitis B vaccination in prisons can protect at least one-third of susceptible inmates.
- Optimizing vaccine schedules and addressing barriers to completion are crucial for improving outcomes.
- Age and history of intravenous drug use were linked to lower vaccine response.