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Ethanol and oral diazepam absorption

S L Hayes, G Pablo, T Radomski

The New England Journal of Medicine

|January 27, 1977

Summary

This summary is machine-generated.

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Ethanol significantly enhances diazepam absorption. Combining alcohol with diazepam nearly doubles peak plasma levels, increasing drug exposure and potential risks.

Area of Science:

Pharmacology
Toxicology
Clinical Medicine

Background:

Ethanol and diazepam are frequently misused together.
Limited understanding exists regarding ethanol's impact on diazepam absorption.

Purpose of the Study:

To investigate the effect of ethanol on the absorption of diazepam in healthy volunteers.

Main Methods:

Seven healthy volunteers received diazepam (0.07 mg/kg) with either water or 30 ml of 50% ethanol.
Plasma diazepam concentrations were measured at various time points post-administration.

Main Results:

Plasma diazepam levels were significantly higher at 60, 90, 120, and 240 minutes when administered with ethanol compared to water alone.
Maximum mean plasma diazepam levels at 60 minutes were nearly double when co-ingested with ethanol (373 ng/mL) versus water (197 ng/mL).

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Conclusions:

Ethanol significantly enhances the absorption of orally administered diazepam.
This enhanced absorption may lead to increased diazepam exposure and potential toxicity when combined with alcohol.