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Related Experiment Videos

Rotator cuff degeneration and lateral epicondylitis: a comparative histological study

M D Chard1, T E Cawston, G P Riley

  • 1Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.

Annals of the Rheumatic Diseases
|January 1, 1994
PubMed
Summary

Degenerative changes in tendons, like rotator cuff tendinitis and lateral epicondylitis, increase with age. Histological analysis revealed similar age-related microscopic changes in different tendon types.

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Area of Science:

  • Orthopedics
  • Histopathology
  • Biomedical Engineering

Background:

  • Rotator cuff tendinitis and lateral epicondylitis are prevalent clinical conditions.
  • The precise pathological mechanisms underlying tendon degeneration remain poorly understood.

Purpose of the Study:

  • To investigate the histological mechanisms of tendon degeneration.
  • To compare pathological changes in rotator cuff tendons and lateral epicondylitis biopsy specimens.

Main Methods:

  • Histological examination of 83 cadaveric rotator cuff tendons (aged 11-94 years).
  • Histological examination of 20 tendon biopsy specimens from patients with lateral epicondylitis (aged 27-56 years).

Main Results:

  • Microscopic changes in lateral epicondylitis biopsies mirrored those in aged rotator cuff tendons.

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  • Observed abnormalities included vascular changes, tenocyte loss, calcification, glycosaminoglycan infiltration, and fibrocartilaginous transformation.
  • Degenerative changes increased with age, with 17% of tendons abnormal below age 39, rising to 40-50% in older individuals.

    • Conclusions:

    • Tendon degeneration shows an increasing incidence with advancing age.
    • Histological findings in lateral epicondylitis common extensor tendons are consistent with age-related changes in supraspinatus tendons.
    • These degenerative changes were absent in control common extensor tendons, suggesting an age-related pathological process.