Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricular epicardial activation sequence in the lamb

J W Mathewson, T A Riemenschneider, H D Ruttenberg

    Pediatric Research
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An unusual cause of severe cyanosis in infancy.

    The Annals of thoracic surgery·2001
    Same author

    Pediatric digital echocardiography: a study of the analog-to-digital transition.

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2000
    Same author

    Automatic control design for a dynamic knee-brace system.

    IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·1999
    Same author

    Pre- and postoperative exercise testing of the child with coarctation of the aorta.

    Pediatric cardiology·1998
    Same author

    Filmless multimedia display following cardiac catheterization.

    Catheterization and cardiovascular diagnosis·1997
    Same author

    Building a pediatric cardiac catheterization laboratory and conference room: design considerations and filmless imaging.

    Pediatric cardiology·1996
    Same journal

    Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.

    Pediatric research·2026
    Same journal

    Interindividual variability in metformin pharmacokinetics in pediatric patients.

    Pediatric research·2026
    Same journal

    Comparison of Crohn's disease exclusion diet and exclusive enteral nutrition in prospectively followed paediatric patients with Crohn's disease.

    Pediatric research·2026
    Same journal

    Natural Language Processing (NLP) tools are superior to ICD-10 codes in capturing clinically relevant information.

    Pediatric research·2026
    Same journal

    Prenatal cannabinoid and nicotine exposure: senescence as a developmental origin of bronchopulmonary dysplasia?

    Pediatric research·2026
    Same journal

    Bob Sun: ECI Biocommentary.

    Pediatric research·2026
    See all related articles

    The ventricular epicardial activation sequence (VEAS) in lambs is similar across ages, adopting an adult pattern by late gestation. This suggests maturational changes in electromechanical events do not influence or are not affected by VEAS.

    Area of Science:

    • Cardiology
    • Developmental Biology
    • Electrophysiology

    Background:

    • The ventricular epicardial activation sequence (VEAS) is crucial for understanding cardiac function.
    • Investigating VEAS in developing animals provides insights into cardiac maturation.

    Purpose of the Study:

    • To determine the VEAS in lambs from late gestation to 3.5 months of age.
    • To assess if VEAS changes with age during early development.
    • To compare neonatal VEAS with that of adult ruminants.

    Main Methods:

    • Simultaneous recording of 40 bipolar electrograms in 15 anesthetized lambs.
    • Computer analysis of cardiac cycles to determine relative activation times.
    • Manual creation of isochrone maps based on signal derivatives.

    Related Experiment Videos

    Main Results:

    • VEAS was consistent across all studied ages, resembling adult ruminant patterns.
    • Earliest left ventricular (LV) activation initiated on the caudal free wall.
    • Right ventricular (RV) activation began simultaneously or slightly later on the ventral surface.
    • Excitation spread circumferentially and apicobasilarly, terminating on the right ventricular outflow tract (RVO).
    • Most epicardial activation completed within 7.5-12.5 msec, with RVO activation taking longer.
    • No significant age-related changes in VEAS duration or pattern were observed.

    Conclusions:

    • The VEAS in lambs assumes an adult-like pattern by late gestation.
    • Maturation of electromechanical events likely does not influence or is not affected by VEAS.
    • VEAS is a stable pattern early in cardiac development.