Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Leukocyte adhesion in ischemia/reperfusion

K Bienvenu¹, D N Granger

¹Department of Physiology, LSU Medical Center, Shreveport 71130-3932.

Blood Cells

|January 1, 1993

Summary

Ischemia/reperfusion triggers an inflammatory response involving leukocyte adhesion in blood vessels. Targeting mediators like platelet activating factor and leukotriene B4 may reduce tissue injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Leukocyte-mediated tissue injury in ischemic stroke.

Current medicinal chemistry·2013

Same author

Microvascular thrombosis and CD40/CD40L signaling.

Journal of thrombosis and haemostasis : JTH·2010

Same author

Role of LPS in the hepatic microvascular dysfunction elicited by cecal ligation and puncture in mice.

Journal of hepatology·2007

Same author

Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia.

Placenta·2006

Same author

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.

American journal of physiology. Gastrointestinal and liver physiology·2006

Same author

Protease chymotrypsin mediates the endothelial expression of P- and E-selectin, but not ICAM and VCAM, induced by placental trophoblasts from pre-eclamptic pregnancies.

Placenta·2003

Area of Science:

Biomedical Science
Inflammation Research
Vascular Biology

Background:

Ischemia/reperfusion (I/R) injury involves complex inflammatory processes.
Leukocyte activation and adhesion are key events in I/R-induced tissue damage.

Purpose of the Study:

To elucidate the mechanisms underlying leukocyte-endothelial cell interactions during I/R.
To identify potential therapeutic targets for mitigating I/R injury.

Main Methods:

Investigated leukocyte rolling, adherence, and emigration in postcapillary venules.
Examined the role of inflammatory mediators (e.g., platelet-activating factor, leukotriene B4).
Assessed the influence of adhesion molecules, reactive oxygen species, and hydrodynamic forces.

Main Results:

I/R significantly increased leukocyte rolling, adherence, and emigration.
Accumulation of mediators like platelet-activating factor and leukotriene B4 was observed.
Adhesion glycoproteins, reactive oxygen metabolites, and neutrophil proteins modulate leukocyte-endothelial interactions.

Conclusions:

The inflammatory response to I/R is mediated by specific molecular and cellular interactions.
Therapeutic strategies targeting these interactions show promise for reducing I/R injury.

Related Experiment Videos