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Viral hepatitis in Bucharest

C Paquet1, V T Babes, J Drucker

  • 1Laboratory of Viral Hepatitis, Stefan Nicolau Institute of Virology, Bucharest, Romania.

Bulletin of the World Health Organization
|January 1, 1993
PubMed
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A 1990 survey in Bucharest found high rates of hepatitis A and B virus (HAV and HBV) infection across all populations, including children and pregnant women. Viral hepatitis is a significant public health issue in Romania, necessitating HBV immunization strategies.

Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Viral hepatitis, including Hepatitis A (HAV), B (HBV), and C (HCV), poses a significant global health challenge.
  • Romania, particularly Bucharest, lacked comprehensive seroprevalence data for viral hepatitis in the early 1990s.

Purpose of the Study:

  • To assess the seroprevalence of Hepatitis A, B, and C virus markers in Bucharest, Romania.
  • To identify high-risk populations and evaluate the burden of viral hepatitis.
  • To inform public health strategies and preventive measures.

Main Methods:

  • A systematic seroprevalence survey was conducted in Bucharest from April to July 1990.
  • A total of 1355 individuals from the general population and high-risk groups were sampled.
Keywords:
AdultAge FactorsChildDemographic FactorsDeveloped CountriesDiseasesEastern EuropeEuropeExaminations And DiagnosesHematologic TestsHepatitisLaboratory Examinations And DiagnosesLaboratory ProceduresPopulationPopulation CharacteristicsResearch ReportRomaniaUrban PopulationViral DiseasesYouth

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  • Sera were tested for HAV, HBV, and HCV markers using enzyme-linked immunosorbent assay (ELISA).

    • Main Results:

    • High prevalences of HAV and HBV markers were observed across all surveyed groups.
    • 47% of adults and 39.8% of children (0-16 years) had at least one HBV marker.
    • Hepatitis B surface antigen was detected in 7.8% of pregnant women, and 54.6% of orphanage-dwelling infants (0-3 years) showed HBV markers. HCV circulation was also confirmed.

    Conclusions:

    • Viral hepatitis represents a major public health problem in Romania.
    • The findings underscore the need for targeted preventive measures, including HBV infant immunization.
    • Further epidemiological studies are required to refine immunization strategies.