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Scleroderma and the carcinoid syndrome
R C Ratnavel1, N P Burrows, R J Pye
1Department of Dermatology, Addenbrooke's Hosital, Cambridge, UK.
Clinical and Experimental Dermatology
|January 1, 1994
Summary
This study reports a carcinoid syndrome case with scleroderma, potentially halted by combined treatment. Tryptophan and serotonin metabolism impairment may link carcinoid skin fibrosis to scleroderma pathogenesis.
Area of Science:
- Medical Science
- Oncology
- Dermatology
Background:
- Carcinoid syndrome can present with scleroderma.
- Skin fibrosis is a key feature in some carcinoid syndrome cases.
- Tryptophan and serotonin metabolism alterations are implicated in carcinoid-related fibrosis.