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Scleroderma and the carcinoid syndrome
R C Ratnavel1, N P Burrows, R J Pye
1Department of Dermatology, Addenbrooke's Hosital, Cambridge, UK.
Clinical and Experimental Dermatology
|January 1, 1994
Abstract:
The follow up of a case of the carcinoid syndrome complicated by scleroderma is reported, in which progress of the disease may have been halted by treatment with a combination of cyproheptadine, parachlorophenylalanine and prednisolone. Impairment of tryptophan and 5-hydroxytryptamine (serotonin) metabolism appears central to the development of skin fibrosis in the carcinoid syndrome and may be indicative of important mechanisms in the pathogenesis of idiopathic scleroderma.