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Gallbladder ejection fraction and its relationship to sphincter of Oddi dysfunction
T A Ruffolo1, S Sherman, G A Lehman
1Indiana University Hospital, Indianapolis 46202-5244.
Digestive Diseases and Sciences
|February 1, 1994
Summary
Sphincter of Oddi dysfunction may cause poor gallbladder emptying, but this study found abnormalities in quantitative cholescintigraphy and manometry to be independent factors in patients with biliary pain.
Area of Science:
- Gastroenterology
- Hepatobiliary Medicine
- Diagnostic Imaging
Background:
- Sphincter of Oddi dysfunction (SOD) is a potential cause of abnormal gallbladder evacuation.
- Quantitative cholescintigraphy is used to assess gallbladder ejection fraction (GBEF).
Purpose of the Study:
- To investigate the relationship between SOD and GBEF assessed by quantitative cholescintigraphy.
- To determine if SOD contributes to poor gallbladder emptying.
Main Methods:
- Eighty-one patients with biliary pain and normal evaluations underwent quantitative cholescintigraphy, sphincter of Oddi manometry, and ERCP.
- Abnormalities were assessed via stimulated quantitative cholescintigraphy and manometry.
Main Results:
- Abnormalities in either quantitative cholescintigraphy or sphincter of Oddi manometry were found in 70% of patients.
- Manometric evidence of SOD occurred with similar frequency regardless of GBEF.
- Abnormalities in quantitative cholescintigraphy and sphincter manometry were independent findings.
Conclusions:
- Quantitative cholescintigraphy and sphincter manometry abnormalities are frequent in patients with biliary pain.
- These abnormalities appear to be independent factors rather than causally linked in this population.