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Related Experiment Videos

The Seattle Alzheimer's disease data set

E M Wijsman1, T D Bird, G M Martin

  • 1Division of Medical Genetics, University of Washington, Seattle 98195.

Genetic Epidemiology
|January 1, 1993
PubMed
Summary

This study describes 40 families with Alzheimer's disease (AD) data, including early-onset and Volga German pedigrees. Genetic markers from chromosomes 19 and 21 were analyzed to understand AD inheritance patterns.

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Area of Science:

  • Genetics
  • Neurology
  • Human Disease

Background:

  • Genetic Analysis Workshop 8 (GAW8) provided a dataset of 40 families.
  • The Seattle dataset includes families typed for genetic markers on chromosomes 19 and 21.
  • Alzheimer's disease (AD) is a complex neurodegenerative disorder with a genetic component.

Purpose of the Study:

  • To describe the characteristics of the 40 families participating in GAW8.
  • To detail the genetic markers and clinical data available for linkage analysis in AD research.
  • To identify early-onset AD families and those of specific descent for further genetic investigation.

Main Methods:

  • Families were selected based on the availability of genetic typing for specific chromosomal regions (chromosome 21 centromeric region, chromosome 19 q arm).

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  • Clinical data, including age of onset and autopsy confirmation of Alzheimer's disease, were collected.
  • Genotype data for three loci on chromosome 19 and four loci on chromosome 21 were utilized.

    • Main Results:

    • The dataset comprises 40 families, with 13 identified as early-onset AD families (average age of onset < 61).
    • Seven families are of Volga German descent.
    • Thirty-four families have autopsy-documented Alzheimer's disease, encompassing all early-onset pedigrees.

    Conclusions:

    • The GAW8 dataset provides a valuable resource for studying the genetic basis of Alzheimer's disease.
    • The inclusion of early-onset and specific descent families allows for targeted genetic analyses.
    • The comprehensive clinical and genetic data facilitate linkage and association studies for AD.