Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monte Carlo analysis on a large pedigree

E A Thompson1, S Lin, A B Olshen

  • 1Department of Statistics, University of Washington, Seattle 98195.

Genetic Epidemiology
|January 1, 1993
PubMed
Summary

Monte Carlo methods were extended for linkage and segregation analysis on the HGAR1 pedigree. These advanced computational approaches were compared to existing methods for genetic analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.

Nature aging·2026
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025

Area of Science:

  • Genetics
  • Computational Biology
  • Statistical Genetics

Background:

  • Linkage and segregation analysis are crucial for understanding genetic inheritance patterns.
  • The HGAR1 pedigree provides a valuable dataset for genetic studies.
  • Existing computational methods may require enhancements for complex genetic data.

Purpose of the Study:

  • To apply and extend Monte Carlo methods for linkage and segregation analysis.
  • To evaluate the performance of these extended methods on the HGAR1 pedigree data.
  • To compare the results with those obtained from the PAP software.

Main Methods:

  • Application of Monte Carlo simulation techniques.
  • Development of extensions to existing Monte Carlo methodologies for genetic analysis.
  • Comparative analysis using the HGAR1 pedigree dataset.

Main Results:

  • Successful application of extended Monte Carlo methods to the HGAR1 pedigree.
  • Demonstration of the utility of the enhanced methods in genetic analysis.
  • Comparison of results with the established PAP software.

Conclusions:

  • Extended Monte Carlo methods offer a robust approach for linkage and segregation analysis.
  • The HGAR1 pedigree is suitable for testing and validating genetic analysis tools.
  • The developed methods provide a valuable alternative or supplement to existing software like PAP.

Related Experiment Videos