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Lymphoid follicles in bone marrow aspirates

K Maeda, B H Hyun, J W Rebuck

American Journal of Clinical Pathology

|January 1, 1977

Summary

Lymphoid follicles in bone marrow aspirates are more common in older adults, especially women. Their increased incidence with plasma-cytosis suggests a response to chronic immune stimulation.

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Area of Science:

Hematology
Immunology
Pathology

Background:

Lymphoid follicles are common in autopsy tissues but less frequently reported in bone marrow aspirates.
Previous studies reported low incidence rates of lymphoid follicles in bone marrow aspirates (3.3-9.1%).

Purpose of the Study:

To determine the incidence of lymphoid follicles in bone marrow aspirates.
To investigate the relationship between lymphoid follicles and patient demographics (age, sex).
To explore the association of lymphoid follicles with other bone marrow findings like plasma-cytosis and lipid granulomas.

Main Methods:

Retrospective analysis of 1,450 consecutive bone marrow aspirates.
Histopathological examination to identify and quantify lymphoid follicles.
Correlation of lymphoid follicle presence with patient age, sex, and other bone marrow features.

Main Results:

Lymphoid follicles were identified in 17.9% of bone marrow aspirates.
Incidence increased significantly after the fourth decade of life, with a higher prevalence in women.
A notable association was found between lymphoid follicles and the presence of plasma-cytosis and/or lipid granulomas.

Conclusions:

The incidence of lymphoid follicles in bone marrow aspirates is higher than previously reported.
Age and sex are significant factors influencing lymphoid follicle occurrence.
The co-occurrence with plasma-cytosis and lipid granulomas suggests a potential role in immune responses to chronic stimulation.

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