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Interleukin-1 and bone metabolism: a review
1Department of Biological and Biophysical Sciences, School of Dentistry, University of Louisville, KY.
Journal of Periodontology
|May 1, 1993
Summary
Interleukin-1 (IL-1) significantly impacts bone metabolism, promoting bone resorption and influencing osteoblastic cells. This cytokine is implicated in periodontal disease pathogenesis, affecting bone and periodontal tissues.
Area of Science:
- Immunology
- Bone Biology
- Periodontology
Background:
- Interleukin-1 (IL-1) is a potent cytokine affecting bone metabolism.
- IL-1 plays a role in various cellular processes, including prostaglandin formation and gene expression in osteoblastic cells.
Purpose of the Study:
- To review the effects of IL-1 on bone metabolism.
- To examine the evidence linking IL-1 to periodontal disease.
- To discuss potential therapeutic strategies targeting IL-1.
Main Methods:
- Review of in vitro and in vivo studies.
- Analysis of IL-1's effects on bone cells and periodontal tissues.
- Examination of bacterial stimulation of IL-1 production.
Main Results:
- IL-1 is a potent bone resorber and can inhibit bone formation.
- Osteoblastic cells express IL-1 receptors and produce IL-1, suggesting autocrine/paracrine roles.
- Elevated IL-1 levels and bacterial stimulation are linked to periodontal tissue breakdown.
Conclusions:
- IL-1 significantly influences bone metabolism and is implicated in bone disease pathogenesis.
- IL-1 is a key factor in periodontal tissue destruction.
- Controlling IL-1 activity may offer therapeutic benefits for periodontal disease.