Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional brain imaging at 1.5 T using conventional gradient echo MR imaging techniques

R T Constable1, G McCarthy, T Allison

  • 1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510.

Magnetic Resonance Imaging
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nature and interpretation of BOLD signals in white matter - A review.

Magnetic resonance imaging·2025
Same author

Whole genome duplication drives transcriptome reprogramming in response to drought in alfalfa.

Plant cell reports·2025
Same author

Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression.

BMC plant biology·2025
Same author

An exploratory study of obstetrics trainees' experiences of breaking bad news.

The clinical teacher·2023
Same author

Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.

AJNR. American journal of neuroradiology·2023
Same author

Reflective practice in psychiatric training: Balint groups during COVID-19.

Irish journal of psychological medicine·2022
Same journal

Incremental diagnostic value of microstructural time-dependent diffusion MRI in differentiating PCNSL from glioblastoma over conventional MRI.

Magnetic resonance imaging·2026
Same journal

Enhanced motion compensation for free-breathing dynamic contrast-enhanced MRI with GROG-facilitated bunch phase encoding and Golden angle radial sampling.

Magnetic resonance imaging·2026
Same journal

The allegory of the cave: 10 years of AI shadows in radiology.

Magnetic resonance imaging·2026
Same journal

Conversion of 3 T liver, spleen, pancreas, and kidney R2* measurements to 1.5 T R2* equivalents: Validation of a theoretical framework.

Magnetic resonance imaging·2026
Same journal

Cine-derived mitral annular relaxation velocity for detection of preclinical left ventricular diastolic dysfunction.

Magnetic resonance imaging·2026
Same journal

Bone marrow fat fraction and R2* in sickle cell disease: Associations with hemolysis, iron metabolism, and disease severity.

Magnetic resonance imaging·2026
See all related articles

Researchers demonstrate that conventional Magnetic Resonance (MR) imaging can effectively map brain activation in visual and motor cortex. This study shows functional brain imaging is feasible on standard clinical scanners, not just high-field ones.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)

Background:

  • Magnetic Resonance (MR) imaging is increasingly used to study brain function.
  • Previous functional MR imaging studies often required high field strengths or specialized echo-planar imaging sequences.
  • Signal intensity changes in T2*-weighted imaging indicate brain activation in response to stimuli.

Purpose of the Study:

  • To investigate the feasibility of using conventional MR imaging methods on a standard 1.5 T clinical scanner for brain activation studies.
  • To demonstrate that functional brain mapping of visual and motor cortex is achievable with widely available clinical MR scanners.

Main Methods:

  • Utilized conventional gradient-echo imaging sequences on a standard 1.5 T clinical MR scanner.
  • Recorded signal intensity changes in response to visual and motor stimuli in normal volunteers.

Related Experiment Videos

  • Employed specific imaging parameters: TE = 45 msec, TR = 120 msec, and alpha = 40 degrees.

    • Main Results:

    • Successfully mapped activated visual and motor cortex areas with high spatial resolution in multiple planes.
    • Observed signal changes ranging from 2-12%, sufficient for clear depiction of activated regions.
    • Demonstrated the capability to record brain activation effects using standard clinical MR imaging.

    Conclusions:

    • Conventional MR imaging on a standard 1.5 T clinical scanner is a viable method for mapping brain activation in visual and motor cortex.
    • This technique offers a practical approach for functional brain studies without requiring high-field magnets or specialized sequences.
    • The findings support the use of accessible MR technology for investigating the relationship between physiological responses and stimulus parameters in the brain.