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Related Experiment Videos

Single cutaneous plasmacytoma with crystalloid inclusions

M Klein, E Grishman

    Archives of Dermatology
    |January 1, 1977
    PubMed
    Summary

    A rare cheek tumor, primary cutaneous plasmacytoma, contained unusual structures within histiocytes. These needle-like crystals, likely phagocytosed plasma cell proteins, were successfully removed, with the patient remaining asymptomatic.

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    Area of Science:

    • Dermatopathology
    • Oncology
    • Cell Biology

    Background:

    • Primary cutaneous plasmacytoma is a rare plasma cell neoplasm affecting the skin.
    • This case presents a unique histological finding in a cheek lesion.

    Observation:

    • Histological examination revealed dense plasma cells and histiocytes with intracellular needle-like structures.
    • Electron microscopy confirmed these structures were membrane-bound, rhombic crystalloids within histiocyte cytoplasm.

    Findings:

    • The intracellular crystalloids are hypothesized to be phagocytosed and stored proteins secreted by plasma cells.
    • This represents a novel observation of extracellular protein deposition within phagocytic cells in cutaneous plasmacytoma.

    Implications:

    • Understanding this phenomenon may offer insights into plasma cell tumor biology and host cell interactions.
    • Complete surgical excision of the tumor led to a favorable patient outcome, suggesting curative potential.

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