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Perforated appendicitis: current experience in a Childrens Hospital
Insights
Surgical treatment of perforated appendicitis in children resulted in no deaths and a 17% complication rate. Key factors included resuscitation, broad-spectrum antibiotics targeting anaerobic bacteria, and surgical precision.
Area of Science:
- Pediatric Surgery
- Infectious Diseases
Background:
- Perforated appendicitis is a serious condition in children.
- High morbidity and mortality rates have historically been associated with this condition.
Purpose of the Study:
- To review outcomes of surgically treated perforated appendicitis in pediatric patients.
- To identify factors contributing to low morbidity and mortality.
Main Methods:
- Retrospective review of 89 consecutive cases of perforated appendicitis.
- Analysis of surgical management, preoperative resuscitation, antibiotic protocols, and postoperative outcomes.
- Microbiological cultures of peritoneal fluid and blood.
Main Results:
- No mortality was observed in the 89 cases.
- A complication rate of 17% was recorded.
- Anaerobic organisms were consistently found in peritoneal fluid and blood cultures, often implicated in infectious complications.
Conclusions:
- Adequate preoperative resuscitation, meticulous surgical technique, and the use of broad-spectrum antibiotics effective against anaerobes are crucial for minimizing complications.
- Targeting anaerobic organisms in antibiotic regimens is essential for managing perforated appendicitis effectively.
Abstract:
A review of 89 consecutive cases of perforated appendicitis recently treated surgically at Childrens Hospital of Los Angeles revealed no mortality and a complication rate of 17%. Significant factors in this low morbidity are: adequate preoperative resuscitation, routine administration of broad spectrum antibiotics pre and postoperatively, and attention to surgical detail. Anaerobic organisms were invariably present in cultures of the peritoneal fluid taken at operation. Anaerobes were also present in the blood in all 5 patients having positive blood cultures and were frequently pathogens whenever postoperative infectious complications occurred. The use of antibiotics effective against anaerobic organisms was common in this series and produced no morbidity.
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