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Transgenic animals as tools in drug development

S Harris1, N K Davis, M I Jowett

  • 1Glaxo Group Research Ltd., Greenford, Middlesex, UK.

Agents and Actions
|January 1, 1993
PubMed
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Transgenic animals, organisms with altered genes, are vital research tools. This review details their creation methods and applications in developing new medicines.

Area of Science:

  • Biotechnology
  • Genetics
  • Animal Models

Background:

  • Transgenic animals are organisms with genetically modified stable genotypes.
  • These animals are increasingly utilized in research and development by academic and commercial entities.

Purpose of the Study:

  • To describe the primary methods for generating transgenic animals.
  • To illustrate the relative merits of different transgenic animal generation approaches.
  • To explore the potential use of transgenic animals in discovering and developing novel therapeutic entities.

Main Methods:

  • Overview of established techniques for genetic manipulation in animals.
  • Comparative analysis of the advantages and disadvantages of various methods.
  • Discussion of applications in preclinical research and drug development.

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Main Results:

  • Detailed description of key methodologies for creating transgenic organisms.
  • Evaluation of the efficiency and applicability of different approaches.
  • Examples of how transgenic models contribute to therapeutic discovery.

Conclusions:

  • Transgenic animal technology offers powerful tools for biological research.
  • Understanding the methods and merits is crucial for their effective application.
  • These models play a significant role in advancing pharmaceutical innovation.