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Lignocaine aerosol and persistent cough

P Howard, R M Cayton, S R Brennan

    British Journal of Diseases of the Chest
    |January 1, 1977
    PubMed
    Summary
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    Lidocaine (lignocaine) aerosol spray provided temporary relief for intractable cough in four patients. Unexpectedly, it sometimes increased airway resistance, suggesting a hypersensitive cough reflex due to airway damage.

    Area of Science:

    • Anesthesiology
    • Pulmonology
    • Pharmacology

    Background:

    • Intractable cough significantly impacts patient quality of life.
    • Current treatments for severe refractory cough have limitations.
    • Airway hypersensitivity is a potential mechanism for chronic cough.

    Purpose of the Study:

    • To evaluate the efficacy of lignocaine aerosol in patients with intractable cough.
    • To investigate the physiological effects of lignocaine on airway resistance in this context.

    Main Methods:

    • Four patients with persistent, severe cough received lignocaine (400 mg) via aerosol.
    • Airway resistance and cough frequency were monitored before and after treatment.

    Main Results:

    Related Experiment Videos

    • All four patients experienced cough improvement lasting one to six weeks.
    • Lignocaine administration paradoxically increased airway resistance in some patients.
    • This suggests a potential role for airway mucosal damage in cough reflex sensitivity.

    Conclusions:

    • Lignocaine aerosol may offer short-term relief for intractable cough.
    • The observed increase in airway resistance highlights potential risks.
    • Further research is needed to understand the mechanism and safety profile of lignocaine for cough suppression.