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IV anaesthesia with propofol using a target-controlled infusion system: comparison with inhalation anaesthesia for
E Doyle1, W McFadzean, N S Morton
1Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.
Insights
Two anesthesia methods for pediatric surgery, propofol-halothane with regional block versus target-controlled propofol infusion with regional block, showed similar safety and recovery.
Area of Science:
- Pediatric Anesthesiology
- General Surgery
- Pharmacology
Background:
- General surgical procedures in children require effective anesthesia.
- Propofol and halothane are common anesthetic agents.
- Regional blocks enhance anesthetic safety and efficacy.
Purpose of the Study:
- To compare the efficacy and safety of two anesthetic techniques in pediatric patients.
- To evaluate propofol-halothane anesthesia with regional block against target-controlled propofol infusion with regional block.
Main Methods:
- Forty children undergoing general surgery were randomly assigned to two groups.
- Group 1 received propofol induction followed by halothane maintenance and regional block.
- Group 2 received target-controlled propofol infusion with regional block, both breathing 67% nitrous oxide in oxygen via laryngeal mask airway.
Main Results:
- Both anesthetic techniques provided adequate anesthesia and operating conditions.
- No significant differences were observed in heart rate, mean arterial pressure, or end-expired carbon dioxide.
- Recovery times were comparable between the two groups.
Conclusions:
- Target-controlled propofol infusion with regional block is a viable alternative to propofol-halothane with regional block for pediatric surgery.
- Both methods ensure comparable anesthetic depth, hemodynamic stability, and recovery profiles in children.
Abstract:
We studied 40 children undergoing general surgical procedures. They were allocated randomly to receive induction of anaesthesia with propofol 3-5 mg kg-1 followed by maintenance with halothane and an appropriate regional block, or induction and maintenance of anaesthesia with a computerized, target-controlled infusion of propofol with a regional block. All patients breathed a mixture of 67% nitrous oxide in oxygen via a laryngeal mask airway. Both techniques provided adequate anaesthesia and operating conditions. There were no significant differences between the groups in heart rate, mean arterial pressure and end-expired carbon dioxide concentration during anaesthesia. There was no significant difference in the recovery times of the two groups.