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Bromine and thyroid hormone activity

P Allain¹, S Berre, N Krari

¹Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.

Journal of Clinical Pathology

|May 1, 1993

Summary

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High plasma bromine concentrations may slightly impact thyroid function. Elevated bromine levels were linked to increased thyroid stimulating hormone (TSH) in patients with thyroid disorders.

Area of Science:

Endocrinology
Clinical Chemistry

Background:

Thyroid hormones regulate metabolism.
Plasma bromine levels can be influenced by environmental factors.
The relationship between bromine and thyroid function requires further investigation.

Purpose of the Study:

To investigate the association between high plasma bromine concentrations and thyroid hormone levels.
To determine if elevated bromine affects free thyroxine (FT4) and thyroid stimulating hormone (TSH).

Main Methods:

Inductively coupled plasma mass spectrometry was used to measure plasma bromine in 799 patients.
Normal bromine concentration was defined as below 6 mg/l.
Comparisons were made between bromine levels, FT4, and TSH values.

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Main Results:

No significant differences in FT4 or TSH levels were observed between patients with low and high bromine concentrations.
A higher percentage of patients with bromine levels above 6 mg/l showed elevated TSH with normal FT4 compared to those with lower bromine levels (p < 0.02).

Conclusions:

Increased plasma bromine may potentiate elevated TSH concentrations.
This effect is likely due to a mild inhibitory impact on thyroid activity.
Further research is warranted to understand the clinical significance of bromine's effect on thyroid function.