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Intravitreal flomoxef sodium in rabbits
K Mochizuki1, M Torisaki, Y Yamashita
1Department of Ophthalmology, School of Medicine, Kanazawa University, Japan.
Ophthalmic Research
|January 1, 1993
Summary
Flomoxef sodium showed undetectable intraocular concentrations in nonvitrectomized rabbit eyes. However, it demonstrated low intravitreal toxicity at 200 micrograms, suggesting potential for treating bacterial endophthalmitis.
Area of Science:
- Ophthalmology
- Pharmacology
- Microbiology
Background:
- Bacterial endophthalmitis is a serious ocular infection.
- Effective intraocular antibiotics are crucial for treatment.
- Flomoxef sodium is a potential candidate antibiotic.
Purpose of the Study:
- To determine the intraocular concentration of flomoxef sodium.
- To evaluate the retinal toxicity of flomoxef sodium.
- To assess the potential of flomoxef sodium for treating bacterial endophthalmitis.
Main Methods:
- Intravenous administration of flomoxef sodium in albino rabbits.
- Measurement of intraocular flomoxef sodium concentration.
- Intravitreal injection of varying doses in rabbits.
- Ophthalmoscopy, electroretinography (ERG), and light microscopy for toxicity assessment.
Main Results:
- Vitreous concentration was undetectable in nonvitrectomized eyes.
- 200 micrograms intravitreal injection showed no ERG changes.
- Higher doses caused transient ERG changes.
- Half-life of 200 micrograms was 4.4 hours.
Conclusions:
- Flomoxef sodium exhibits low intravitreal toxicity at effective concentrations.
- Its broad antibacterial spectrum and safety profile suggest utility in bacterial endophthalmitis treatment.