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The modulation of ocular growth in rabbits with peripheral retinal ablation
W G Whitmore1, B J Curtin, D Fox
1Department of Ophthalmology, New York Hospital-Cornell University Medical Center, New York.
Purpose:
To study the effects of transcleral cryotherapy and laser photocoagulation of anterior retina on ocular growth.
Methods:
Twenty-one rabbits underwent transcleral cryotherapy or indirect ophthalmoscopic laser photocoagulation of the anterior retina on one of their eyes between 2 and 8 weeks of age.
Results:
After the rabbits were killed between 3 and 6 months of age, treated rabbit eyes were found to be significantly smaller in axial length (P < 0.001), average equatorial diameter (P < 0.01), average corneal diameter (P < 0.05), and in total ocular volume (P < 0.01). The difference in eye size was not due to lowered intraocular pressure.
Conclusions:
The results demonstrate that these treatments slow growth of both the anterior and posterior segment of rabbit eyes.